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Year Number of Results
2004 1
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2007 3
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34 results

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Page 1
DDAH1 Promotes Lung Endothelial Barrier Repair by Decreasing Leukocyte Transendothelial Migration and Oxidative Stress in Explosion-Induced Lung Injury.
Cong P, Tong C, Mao S, Shi L, Shi X, Liu Y, Jin H, Liu Y, Hou M. Cong P, et al. Oxid Med Cell Longev. 2022 May 17;2022:8407635. doi: 10.1155/2022/8407635. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35620579 Free PMC article.
To explore the mechanism of vascular injury in blast lung, 40 C57BL/6 wild type mice and 40 DDAH1 knockout mice were randomly equally divided into control group and blast group, respectively. ...Our results indicated that explosion could induce severe lung in …
To explore the mechanism of vascular injury in blast lung, 40 C57BL/6 wild type mice and 40 DDAH1 knockout mice were randomly …
DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells.
Trittmann JK, Almazroue H, Jin Y, Nelin LD. Trittmann JK, et al. Physiol Rep. 2019 Jul;7(12):e14150. doi: 10.14814/phy2.14150. Physiol Rep. 2019. PMID: 31209995 Free PMC article.
Both DDAH1 siRNA- and ADMA-treated hfPMVEC had greater numbers of viable cells than controls. ...Our findings suggest that DDAH1 may be a potential therapeutic target in pulmonary hypertensive disorders....
Both DDAH1 siRNA- and ADMA-treated hfPMVEC had greater numbers of viable cells than controls. ...Our findings suggest that DDAH1 …
Dimethylarginine dimethylaminohydrolase 1 protects PM(2.5) exposure-induced lung injury in mice by repressing inflammation and oxidative stress.
Gao J, Lei T, Wang H, Luo K, Wang Y, Cui B, Yu Z, Hu X, Zhang F, Chen Y, Ding W, Lu Z. Gao J, et al. Part Fibre Toxicol. 2022 Oct 14;19(1):64. doi: 10.1186/s12989-022-00505-7. Part Fibre Toxicol. 2022. PMID: 36242005 Free PMC article.
However, the impact of DDAH1/ADMA on PM(2.5)-induced lung injury has not been investigated. ...In addition, exogenous ADMA administration could mimic the effect of Ddah1 deficiency on PM(2.5)-induced lung injury, oxidative stress and inflammation. ...
However, the impact of DDAH1/ADMA on PM(2.5)-induced lung injury has not been investigated. ...In addition, exogenous ADMA adm …
Expression of DDAH1 in chick and rat embryos.
Mishima T, Hamada T, Ui-Tei K, Takahashi F, Miyata Y, Imaki J, Suzuki H, Yamashita K. Mishima T, et al. Brain Res Dev Brain Res. 2004 Feb 20;148(2):223-32. doi: 10.1016/j.devbrainres.2003.09.021. Brain Res Dev Brain Res. 2004. PMID: 14766200
DDAH1 was also detected in the brain, kidney, digestive tract, and in other tissues. ...Our study suggests that DDAH1 plays an important role in development....
DDAH1 was also detected in the brain, kidney, digestive tract, and in other tissues. ...Our study suggests that DDAH1 plays an …
Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.
Swärd K, Sadegh MK, Mori M, Erjefält JS, Rippe C. Swärd K, et al. Physiol Rep. 2013 Jun;1(1):e00008. doi: 10.1002/PHY2.8. Epub 2013 Jun 7. Physiol Rep. 2013. PMID: 24303100 Free PMC article.
Bright field and electron-microscopy showed that the cavin-1-deficient mice lacked caveolae in the lung, had an increased lung tissue density, and exhibited hypertrophic remodeling of pulmonary arteries. ...A microarray analysis revealed upregulation of Arg1 and dow …
Bright field and electron-microscopy showed that the cavin-1-deficient mice lacked caveolae in the lung, had an increased lung …
Chitosan oligosaccharide ameliorates acute lung injury induced by blast injury through the DDAH1/ADMA pathway.
Liu YE, Tong CC, Zhang YB, Cong PF, Shi XY, Liu Y, Shi L, Tong Z, Jin HX, Hou MX. Liu YE, et al. PLoS One. 2018 Feb 7;13(2):e0192135. doi: 10.1371/journal.pone.0192135. eCollection 2018. PLoS One. 2018. PMID: 29415054 Free PMC article.
COS significantly increased dimethylarginine dimethylaminohydrolase 1 (DDAH1) protein expression, and reduced ADMA and p38 protein expression (P< 0.05). CONCLUSION: Blast injury causes inflammation, oxidative stress and apoptosis in the lung tissues of mice. COS …
COS significantly increased dimethylarginine dimethylaminohydrolase 1 (DDAH1) protein expression, and reduced ADMA and p38 protein ex …
Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice.
Hannemann J, Glatzel A, Hillig J, Zummack J, Schumacher U, Lüneburg N, Harbaum L, Böger R. Hannemann J, et al. Front Physiol. 2020 Nov 12;11:597559. doi: 10.3389/fphys.2020.597559. eCollection 2020. Front Physiol. 2020. PMID: 33281630 Free PMC article.
Methods: Ddah1 KO mice and their wild-type (WT) littermates were subjected to normoxia (NX) or for 21 days. ...Results: Ddah1 KO mice had higher ADMA concentrations in plasma and in lung tissue than WT in NX (p < 0.05). ...
Methods: Ddah1 KO mice and their wild-type (WT) littermates were subjected to normoxia (NX) or for 21 days. ...Results: Ddah1 …
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Xu X, Zhang P, Kwak D, Fassett J, Yue W, Atzler D, Hu X, Liu X, Wang H, Lu Z, Guo H, Schwedhelm E, Böger RH, Chen P, Chen Y. Xu X, et al. Basic Res Cardiol. 2017 Aug 17;112(5):55. doi: 10.1007/s00395-017-0644-z. Basic Res Cardiol. 2017. PMID: 28819685 Free PMC article.
In the heart, DDAH1 is observed in endothelial cells and in the sarcolemma of cardiomyocytes. While NO signaling is important for cardiac adaptation to stress, DDAH1 impact on cardiomyocyte homeostasis is not clear. Here we used the MerCreMer-LoxP model to specifica …
In the heart, DDAH1 is observed in endothelial cells and in the sarcolemma of cardiomyocytes. While NO signaling is important for car …
Human pulmonary microvascular endothelial cell DDAH1-mediated nitric oxide production promotes pulmonary smooth muscle cell apoptosis in co-culture.
Almazroue H, Jin Y, Nelin LD, Barba JC 2nd, Milton AD, Trittmann JK. Almazroue H, et al. Am J Physiol Lung Cell Mol Physiol. 2023 Sep 1;325(3):L360-L367. doi: 10.1152/ajplung.00433.2021. Epub 2023 Jul 11. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37431589
Asymmetric dimethylarginine (ADMA) is an endogenous eNOS inhibitor, primarily metabolized by dimethylarginine dimethylaminohydrolase-1 (DDAH1). Our hypothesis is that DDAH1 knockdown in human pulmonary microvascular endothelial cells (hPMVEC) will result in lower NO …
Asymmetric dimethylarginine (ADMA) is an endogenous eNOS inhibitor, primarily metabolized by dimethylarginine dimethylaminohydrolase-1 (D …
DDAH1 SNP rs480414 that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia results in lower nitric oxide production in neonatal cord blood-derived lymphoblastoid cell lines.
Milton AD, Almazroue H, Jin Y, Zender G, Trittmann JK. Milton AD, et al. J Neonatal Perinatal Med. 2022;15(1):113-121. doi: 10.3233/NPM-210710. J Neonatal Perinatal Med. 2022. PMID: 34151866 Free PMC article.
We tested the hypothesis that DDAH1 SNP (AA) results in DDAH1 gain of function, leading to greater NO-mediated apoptosis compared to DDAH1 wild-type (GG) in LCLs. METHODS: LCLs were analyzed by Western blot (DDAH1, cleaved and total caspase-3 and -8, a …
We tested the hypothesis that DDAH1 SNP (AA) results in DDAH1 gain of function, leading to greater NO-mediated apoptosis compa …
34 results